Full List of Publications with TOC

2024

(213) Gazzi, T.; Heinke, M.; Landolt, F.; Bode, J. W. external pageChemical Synthesis of Secretoglobin 3A2 Covalent Homodimer and Photocaged Monomeric Variants Angew. Chem. Int. Ed. 2024, e202404992.

(212) Weidner, P.; Saar, D.; Söhn, M.; Schroeder, T.; Yu, Y.; Zöllner, F. G.; Ponelies, N.; Zhou, X.; Zwicky, A.; Rohrbacher, F. N.; Pattabiraman, V. R.; Tanriver, M.; Bauer, A.; Ahmed, H.; Ametamey, S.M.; Riffel, P.; Seger, R.; Bode, J. W.; Wade, R. C.; Ebert, M. P.A.; Kragelund, B. B.; Burgermeister, E. external pageMyotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction Cancer Letters 2024, 588, 216783.

(211) Tanriver M.; Müller M.; Levavsseur M. D.; Richards D.; Majima S.; deMello A.; Yamauchi Y.; Bode, J. W. external pagePeptide-Directed Attachment of Hydroxylamines to Specific Lysines of IgG Antibodies for Bioconjugations with Acylboronates Angew. Chem. Int. Ed. 2024, Early View.

Preprint: external pagehttps://doi.org/10.26434/chemrxiv-2023-4f6kr

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2023

(210) Götz, J.; Jackl, M. K.; Jindakun, C.; Marziale, A. N.; André, J.; Gosling, D. J.; Springer, C.; Palmieri, M.; Reck, M.; Luneau, A.; Brocklehurst, C. E.; Bode, J. W. external pageHigh-Throughput Synthesis Provides Data for Predicting Molecular Properties and Reaction Success. Sci. Adv. 2023, 9, eadj2314.

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(207) Coin, G.; Jiang T.; Bordi, S.; Nichols, P. L.; Bode, J. W.; Wanner, B.  external pageAutomated, Capsule-Based Suzuki–Miyaura Cross Couplings.external page Org. Lett2023, ASAP Article.

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(206) Beyer, D.; Vaccarin, C.; Deupi, X.; Mapanao, A. K.; Cohrs, S.; Sozzi-Guo, F.; Grundler, P. V.; van der Meulen, N. P.; Wang, J.; Tanriver, M.; Bode, J. W.; Schibli, R.; Müller, C. external pageA tool for nuclear imaging of the SARS-CoV-2 entry receptor: molecular model and preclinical development of ACE2-selective radiopeptides. EJNMMI Research 2023, 13, 32.

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(204) Farnung, J.; Tolmachova, K. A.; Bode, J. W. external pageInstallation of electrophiles onto the C-terminus of recombinant ubiquitin and ubiquitin-like proteins Chem. Sci. 2023, 14, 121-129.

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2022

(203) MacMillan, A. E.; Wu, W. W. X.; Nichols, P. L.; Wanner, B. M.; Bode, J. W. external pageA Vending Machine for Drug-like Molecules – Automated Synthesis of Virtual Screening Hits Chem. Sci. 2022, 13, 14292-14299.

-Preprint: external pagehttps://doi.org/10.26434/chemrxiv-2022-htpw2

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(202) Scott, T. A.; Verest, M.; Farnung, J.; Forneris, C. C.; Robinson, S. L.; Ji, X.; Hubrich, F.; Chepkirui, C.; Richter, D. U.; Huber, S.; Rust, P.; Streiff, A. B.; Zhang, Q.; Bode, J. W.; Piel, J. external pageWidespread Microbial Utilization of Ribosomal β-Amino Acid-Containing Peptides and Proteins. Chem 2022, 8, 2659–2677.

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(201) Kumarswamyreddy, N.; Nakagawa, A.; Endo, H.; Shimotohno, A.; Torii, K. U.; Bode, J. W.; Oishi, S. external pageChemical Synthesis of the EPF-Family of Plant Cysteine-Rich Proteins and Late-Stage Dye Attachment by Chemoselective Amide-Forming Ligations. RSC Chem. Biol. 2022. https://doi.org/10.1039/D2CB00155A.

(200) Levasseur, M. D.; Hofmann, R.; Edwardson, T. G. W.; Hehn, S.; Thanaburakorn, M.; Bode, J. W.; Hilvert, D. external pagePost-Assembly Modification of Protein Cages by Ubc9-Mediated Lysine Acylation. ChemBioChem 2022, e202200332.

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(199) Nakamuro, T.; Kamei, K.; Sun, K.; Bode, J. W.; Harano, K.; Nakamura, E. external pageTime-Resolved Atomistic Imaging and Statistical Analysis of Daptomycin Oligomers with and without Calcium Ions. J. Am. Chem. Soc. 2022, 144, 13612–13622.

- Preprint: external pagedoi.org/10.26434/chemrxiv-2022-xdkxs-v2

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(198) Tolmachova, K. A.; Farnung, J.; Liang, J. R.; Corn, J. E.; Bode, J. W. external pageFacile Preparation of UFMylation Activity-Based Probes by Chemoselective Installation of Electrophiles at the C-Terminus of Recombinant UFM1. ACS Cent. Sci. 2022, 8, 756–762.

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(197) Kumarswamyreddy, N.; Reddy, D. N.; Robkis, D. M.; Kamiya, N.; Tsukamoto, R.; Kanaoka, M. M.; Higashiyama, T.; Oishi, S.; Bode, J. W. external pageChemical Synthesis of Torenia Plant Pollen Tube Attractant Proteins by KAHA Ligation. RSC Chem. Biol. 2022, 3, 721–727.

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(195) Škopić, M. K.; Losch, F.; McMillan, A. E.; Willeke, N.; Malenica, M.; Bering, L.; Bode, J.; Brunschweiger, A. external pageReagent-Based Scaffold Diversity for DNA-Encoded Library Design: Solid Phase Synthesis of DNA-Tagged Sp3-Rich Heterocycles by SnAP Chemistry. Org. Lett. 2022, 24, 1383–1387.
 

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2021

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(193) Müller, M.; Gräbnitz, F.; Barandun, N.; Shen, Y.; Wendt, F.; Steiner, S. N.; Severin, Y.; Vetterli, S. U.; Mondal, M.; Prudent, J. R.; Hofmann, R.; van Oostrum, M.; Sarott, R. C.; Nesvizhskii, A. I.; Carreira, E. M.; Bode, J. W.; Snijder, B.; Robinson, J. A.; Loessner, M. J.; Oxenius, A.; Wollscheid, B. external pageLight-Mediated Discovery of Surfaceome Nanoscale Organization and Intercellular Receptor Interaction Networks. Nat. Commun. 2021, 12, 7036.

- Preprint: external pagedoi.org/10.1101/2020.08.11.246652

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(191) Farnung, J.; Song, H.; Bode, J. W. external pageChemical Protein Synthesis by Chemoselective #x03B1;-Ketoacid–Hydroxylamine (KAHA) Ligations with 5-Oxaproline. In: Hussein W.M., Stephenson R.J., Toth I. (eds) Peptide Conjugation. Methods in Molecular Biology, vol 2355. Humana, New York, NY, 2021; pp 151–162.

(190) Fracassi, A.; Ray, A.; Nakatsuka, N.; Passiu, C.; Tanriver, M.; Schauenburg, D.; Scherrer, S.; Ouald Chaib, A.; Mandal, J.; N. Ramakrishna, S.; W. Bode, J.; D. Spencer, N.; Rossi, A.; Yamakoshi, Y. external pageKAT Ligation for Rapid and Facile Covalent Attachment of Biomolecules to Surfaces. 2021, ASAP article

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(189) Bhatt, P. R.; Scaiola, A.; Loughran, G.; Leibundgut, M.; Kratzel, A.; Meurs, R.; Dreos, R.; O’Connor, K. M.; McMillan, A.; Bode, J. W.; Thiel, V.; Gatfield, D.; Atkins, J. F.; Ban, N. external pageStructural Basis of Ribosomal Frameshifting during Translation of the SARS-CoV-2 RNA Genome. Science 2021, eabf3546.

- Preprint: external pagedoi.org/2020.10.26.355099

- Highlighted in ETH News

(188) Jiang, T.; Bordi, S.; McMillan, A. E.; Chen, K.-Y.; Saito, F.; Nichols, P. L.; Wanner, B. M.; Bode, J. W. external pageAn Integrated Console for Capsule-Based, Automated Organic Synthesis. Chem. Sci. 2021, 12, 6977-6982.

- Preprint: external pagedoi.org/10.26434/chemrxiv.7882799.v1

- Preprint highlighted in external pageNature 2019, 568, 577-​579.

(187) Matabaro, E.; Kaspar, H.; Dahlin, P.; Bader, D. L. V.; Murar, C. E.; Staubli, F.; Field, C. M.; Bode, J. W.; Künzler, M. external pageIdentification, heterologous production and bioactivity of lentinulin A and dendrothelin A, two natural variants of backbone N-methylated peptide macrocycle omphalotin A. Sci. Rep. 2021, 11, 3541.

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2020

(185) Jackl, M. K.; Gordon, C. P.; Copéret, C.; Bode, J. W. external pageSpirocyclic Nitroxide Biradicals: Synthesis and Evaluation as Dynamic Nuclear Polarizing Agents. Helv. Chim. Acta 2020, 3, e2000179.

(184) Song, H.; Wu, D.; Mazunin, D.; Liu, S.M.; Sato, Y.; Broguiere, N.; Zenobi-Wong, M.; Bode, J..W.; external page"Post‐assembly Photomasking of Potassium Acyltrifluoroborates (KATs) for Two‐Photon 3D Patterning of PEG‐Hydrogels", Helv. Chim. Acta. 2020, 103, e2000172.

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(183) Hofmann, R.; Akimoto, G.; Wucherpfennig, T. G., Zeymer, C., Bode, J. W.;external page"Lysine Acylation Using Conjugating Enzymes (LACE) for Site-Specific Modification and Ubiquitination of Native Proteins", Nat. Chem. 2020, 12, 10081015.

- highlighted in external pageNat. Chem. 2020, 12, 980-982.

- cover picture external pageNat. Chem. 2020, 12(11).

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(182) Weidner, P.; Söhn, M.; Schroeder, T.; Helm, L.; Hauber, V.; Gutting, T.; Betge, J.; Röcken, C.; Rohrbacher, F. N.; Pattabiraman, V. R.; Bode, J. W.; Seger, R.; Saar, D.; Nunes-Alves, A.; Wade, R. C.; Ebert, M. P. A.; Burgermeister, E.; external pageMyotubularin-Related Protein 7 Activates Peroxisome Proliferator-Activated Receptor-Gamma, Oncogenesis 2020, 9, 59.

(181) Wu, D.; Taguchi, J.; Tanriver, M.; Bode, J..W.; external pageSynthesis of Acylboron Compounds. Angew. Chem. Int. Ed. 2020, 59, 16847–16858.

(180) Osuna Gálvez, A.; Bode, J. W.; external page"Synthesis of Amides from Acylboron Compounds" Science of Synthesis Knowledge Updates 2020, 1, 375.

(179) Broguiere, N.; Lüchtefeld, I.; Trachsel, L.; Mazunin, D.; Rizzo, R.; Bode, J. W.; Lutolf, M. P.; Zenobi‐Wong, M.; external page"Morphogenesis Guided by 3D Patterning of Growth Factors in Biological Matrices" Adv. Mater. 2020, 1908299.

(178) Schauenburg, D.; Divandari, M.; Neumann, K.; Spiegel, C.A.; Hackett, T.; Dzeng, Y.; Spencer, N.D.; Bode, J..W.; external page"Synthesis of polymers containing potassium acyltrifluoroborates (KATs) and post‐polymerization ligation and conjugation" Angew. Chem. Int. Ed. 2020, 59, 14656–14663.

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(175) Murar, C. E.; Ninomiya, M.; Shimura, S.;  Karakus, K.; Boyman, O.; Bode, J. W.; external page"Chemical Synthesis of Interleukin‐2 and Disulfide Stabilizing Analogues" Angewandte Chem. Int. Ed. 2020, 59, 8425–8429.

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(174) Stepek, I., A.; Hofmann, R.; Nichols, P.; Aschwanden, A.; Eckhard, C.; Aschwanden, P.; Bode, J. W.; "external pageMake a Molecule: A Synthetic Organic and Medicinal Chemistry Workshop Program for High School Students" J. Chem. Educ. 2020, 2, 402-413.

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(173) Baldauf, S.; Ogunkoya, A. O.; Boross, G. N.; Bode, J. W.; "external pageAspartic Acid Forming α-Ketoacid–Hydroxylamine (KAHA) Ligations with (S)-4,4-difluoro-5-oxaproline" J. Org. Chem. 20203, 1352-1364.

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(172) Chiotellis, A.; Ahmed, H.; Betzel, T.; Tanriver, M.; White, C. J.; Song, H.; Da Ros, S.; Schibli, R.; Bode, J. W.; Ametamey, S. M.; "external pageChemoselective 18F-incorporation into pyridyl acyltrifluoroborates for rapid radiolabelling of peptides and proteins at room temperature" Chem. Commun2020, 56, 723-726.

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2019

(171)  Zhang, Y.; Hirota, T.; Kuwata, K.; Oishi, S.;Gramani, S.G.; Bode, J.W.; external page"Chemical Synthesis of Atomically Tailored SUMO E2 Conjugating Enzymes for the Formation of Covalently Linked SUMO–E2–E3 Ligase Ternary Complexes" J. Am. Chem. Soc. 2019, 141, 14742-14751.

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(170) Baldauf, S.; Schauenburg, D.; Bode, J. W.; external page"A threonine‐forming oxazetidine amino acid for the chemical synthesis of proteins with the KAHA ligation" Angew. Chem. Int. Ed. 2019, 58, 1–6.

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(168) Osuna Gálvez, A.; Bode, J. W.; external page"Traceless Templated Amide-Forming Ligations" J. Am. Chem. Soc. 2019, 1418721-8726.

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(165) Saito, F.; Trapp, N.; Bode, J. W. external page"Iterative Assembly of Polycyclic Saturated Heterocycles from Monomeric Building Blocks" J. Am. Chem. Soc. 2019141, 5544–5554

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(164) Luescher, M. U.; Bode, J. W. external page"Evidence for a Radical Mechanism in Cu(II)-Promoted SnAP Reactions" Synlett 2019, 30, A–G

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(163) Book: Pattabiraman, V. R.; Ogunkoya, A. O.; Bode, J. W. external page"Amide-Forming Ligation Reactions" Organic Reactions (Vol. 97) [Ed: Scott E. Denmark et al.], John Wiley & Sons, Inc.

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(161) Boross, G. N.; Schauenburg, D.; Bode, J. W. external page"Chemoselective derivatization of folded synthetic insulin variants with potassium acyltrifluoroborates (KATs)" Helv. Chim. Acta 2019, 102, e1800214.

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2018

(160) Vagstad, A. L.; Kuranaga, T.; Püntener, S.; Pattabiraman, V. R.; Bode, J. W.; Piel, J. external page"Introduction of D‐Amino Acids in Minimalistic Peptide Substrates by an S‐Adenosyl‐L‐Methionine Radical Epimerase" Angew. Chem. Int. Ed. 2018, 58, 2246-2250

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(159) Gu, Y.; Schauenburg, D.; Bode, J. W.; Johnson, J. A. external page"Leaving Groups as Traceless Topological Modifiers for the Synthesis of Topologically Isomeric Polymer Networks" J. Am. Chem. Soc. 2018140, 14033–14037

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(157) Luescher, M. U.; Jindakun, C.; Bode, J. W. external page"Preparation of Tributyl(iodomethyl)stannane" Org. Synth. 2018, 95, 345-356

(156) Boross, G. N.; Shimura, S.; Besenius, M.; Tennagels, N.; Rossen, K.; Wagner, M.; Bode, J. W. external page"Facile folding of insulin variants bearing a prosthetic C-peptide prepared by α-ketoacid-hydroxylamine (KAHA) ligation"  Chem. Sci. 2018, 9, 8388-8395

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(155) Murar, C. E.; Harmand, T. J.; Takano, H.; Bode, J. W. external page"Preparation of (S)-N-Boc-5-oxaproline" Org. Synth. 2018, 95, 157-176

(154) Harmand, T. J.; Murar, C. E.; Takano, H.; Bode, J. W. external page"Enantioselective Synthesis of (S)-Ethyl 2-((tert-butoxycarbonyl)((tert-butyldimethylsilyl)oxy)amino)-4-oxobutanoate" Org. Synth. 2018, 95, 142-156

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(152) Jackl, M.; Schuhmacher, A.; Shiro, T.; Bode, J. W.; external page"Synthesis of N,N-Alkylated α-Tertiary Amines by Coupling of α-Aminoalkyltrifluoroborates and Grignard Reagents" Org. Lett. 2018, 20, 4044–4047

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(150) Rohrbacher, F.; Zwicky, A.; Bode, J. W.; external page"Facile Synthesis of Internal and C-Terminal Peptide α-Ketoamides with Fmoc-Solid Phase Peptide Synthesis" Helv. Chim. Acta 2018, 101e1800039

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(149) Review article: Stepek, I. A.; Bode, J. W.; external page"Synthetic fermentation of bioactive molecules" Curr. Opin. Chem. Biol. 201846, 18–24

(148) Liu, S. M.; Wu, D.; Bode, J. W.; external page"One-Step Synthesis of Aliphatic Potassium Acyltrifluoroborates (KATs) from Organocuprates" Org. Lett. 2018, 20, 2378–2381

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(147) Jindakun, C.; Hsieh, S.-Y.; Bode, J. W.; external page"Iridium-catalyzed Synthesis of Saturated N‐Heterocycles from Aldehydes and SnAP Reagents with Continuous Flow Photochemistry" Org. Lett. 201820, 2071–2075
external pagereviewed in Synfacts 2018, 12, 629 

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(146) Hubert, J. G.; Stepek, I. A.; Noda, H.; Bode, J. W.; external page"Synthetic Fermentation of β-peptide Macrocycles by Thiadiazole-Forming Ring-Closing Reactions" Chem. Sci. 20189, 2159–2167 
- external pagehighlighted in Chimia 201872, 338

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2017

(144) Luescher, M. U.; Songsichan, T.; Hsieh, S.-Y.; Bode, J. W.; external page"Copper Promoted Oxidative Coupling of SnAP Hydrazines and Aldehydes to Form Chiral 1,4,5-Oxadiazepanes and 1,2,5-Triazepanes" Helv. Chim. Acta 2017, 100, e1700199

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(143) Taguchi, J.; Ikeda, T.; Takahashi, R.; Sasaki, I.; Ogasawara, Y.; Dairi, T.; Kato, N.; Yamamoto, Y.; Bode, J. W.; Ito, H. external page"Synthesis of Acylborons by Ozonolysis of Alkenylboronates: Preparation of an Enantioenriched Amino Acid Acylboronate" Angew. Chem. Int. Ed. 201756, 13847–13851external page

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(141) Harmand, T. J.; Pattabiraman, V. R.; Bode, J. W. external page"Chemical Synthesis of the Highly Hydrophobic Antiviral Membrane Associated Protein IFITM3 and Modified Variants" Angew. Chem. Int. Ed. 201756, 12639–12643

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(140) Jackl, M. K.; Legnani, L.; Morandi, B.; Bode, J. W. external page"Continuous Flow Synthesis of Morpholines and Oxazepanes with Silicon Amine Protocol (SLAP) Reagents and Lewis Acid Facilitated Photoredox Catalysis" Org. Lett.201719, 4696–4699
external pagehighlighted in Org. Process Res. Dev. 201721, 1453–1463

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(139) Rohrbacher, F.; Baldauf, S.; Wucherpfennig, T. G.; Bode, J. W. external page"Product Selectivity in KAHA Ligations: Ester vs. Amide Formation with Cyclic Hydroxylamines" Synlett. 201728, 1929–1933

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(138) Murar, C. E.; Harmand, T. J.; Bode, J. W. external page"Improved synthesis of (S)-N-Boc-5-oxaproline for protein synthesis with the α-ketoacid-hydroxylamine (KAHA) ligation" Bioorg. Med. Chem. 2017, 25, 4996–5001

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(135) Osuna Gálvez, A.; Schaack, C. P.; Noda, H.; Bode, J. W. external page"Chemoselective acylation of primary amines and amides with potassium acyltrifluoroborates under acidic conditions" J. Am. Chem. Soc. 2017, 139, 1826–1829
external pagehighlighted in Org. Process Res. Dev. 201721, 279–291

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2016

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(129) Book chapter: Chiang, P.-C.; Bode, J. W. external page"N-Heterocyclic Carbenes as Organic Catalysts" N-Heterocyclic Carbenes: From Laboratory Curiosities to Efficient Synthetic Tools (Edition 2) [Ed: Silvia Diez-Gonzalez]

(128) Perspective: Saito, F.; Bode, J. W. "external pageMacrocyclic Peptides: Tying Up Loose EndsNature Chem. 2016, 8, 1085-1086

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(127) Perspective: Hofmann, R.; Bode, J. W. external page"A Radical Approach to Posttranslational Mutagenesis" Science 2016354, 553–554. 

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(126) Liu, S. M.; Mazunin, D.; Pattabiraman, V. R.; Bode, J. W. external page"Synthesis of Bifunctional Potassium Acyltrifluoroborates" Org. Lett. 2016, 18, 5336–5339

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(125) Thuaud, F.; Rohrbacher, F.; Zwicky, A.; Bode, J. W. external page"Photoprotected Peptideα-Ketoacids and Hydroxylamines for Iterative and One-Pot KAHA Ligations: Synthesis of NEDD8" Helv. Chim. Acta 2016, 99, 868–894

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(124) Trindade, A. F.; Bode, J. W. external page"Irreversible Conjugation of Aldehydes in Water To Form Stable 1,2,4-Oxadiazinan-5-ones" Org. Lett. 201618, 4210–4213

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(123) Wucherpfennig, T. G.; Müller, S; Wolfrum, C.; Bode, J. W. external page"Chemical Synthesis of the 12 kDa Human Myokine Irisin byα-Ketoacid-Hydroxylamine (KAHA) Ligation" Helv. Chim. Acta 201699, 897–907

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(122) Thuaud, F.; Rohrbacher, F.; Zwicky, A.; Bode, J. W. external page"Incorporation of Acid-Labile Masking Groups for the Traceless Synthesis of C-Terminal Peptide α-Ketoacids" Org. Lett. 201618, 3670–3673

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(121) Harmand, T. J.; Murar, C. E.; Bode, J. W. external page"Protein chemical synthesis by α-ketoacid-hydroxylamine ligation" Nature Protocols 2016, 11, 1130-1147

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(118) Jackl, M. K.; Kreituss, I.; Bode J. W.; external page"Synthesis of Tetrahydronaphthyridines from Aldehydes and HARP Reagents via Radical Pictet–Spengler Reactions" Org. Lett. 2016, 18, 1713–1715
external pagereviewed in Synfacts 201612, 0569

(117) Kreituss, I.; Chen, K.-Y.; Eitel, S. H.; Adam, J.-M.; Wuitschik, G.;Fettes, A.; Bode, J. W. external page"A Robust, Recyclable Resin for Decagram Scale Resolution of (±)-Mefloquine and Other Chiral N-Heterocycles" Angew. Chem. Int. Ed. 2016, 55, 1553–1556.
external pagereviewed in Synfacts 201612, 0422. 

2015

(115) He, C.; Kulkarni, S. S.; Thuaud, F.; Bode, J. W. external page"Chemical Synthesis of the 20 kDa Heme Protein Nitrophorin 4 by α-Ketoacid-Hydroxylamine (KAHA) Ligation" Angew. Chem. Int. Ed. 2015, 54, 12996–13001.

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(114) Wanner, B.; Kreituss, I.; Gutierrez, O.; Kozlowski, M. C.; Bode, J. W. external page"Catalytic Kinetic Resolution of Disubstituted Piperidines by Enantioselective Acylation: Synthetic Utility and Mechanistic Insights" J. Am. Chem. Soc. 2015137, 11491–11497.

(113) Review article: Luescher, M. U.; Geoghegan, K.; Nichols, P. L.; Bode, J. W. external page"SnAP Reagents for a Cross-Coupling Approach to the One-Step Synthesis of Saturated N-Heterocycles"Aldrichim. Acta 201548, 43–48.

(112) Luescher, M. U.; Bode, J. W. external page"Catalytic Synthesis of N-Unprotected Piperazines, Morpholines, and Thiomorpholines from Aldehydes and SnAP Reagents" Angew. Chem. Int. Ed. 201554, 10884–10888.
- SnAP reagents are commercially available on external pageSIGMA-ALDRICH!

(111)  Pusterla, I.; Bode, J. W. external page"An oxazetidine amino acid for chemical protein synthesis by rapid, serine-forming ligations" Nature Chem. 20157, 668–672.
- external pagereviewed in Synform 2016, 02, A29-A31

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(110) Rohrbacher, F.; Deniau, G.; Luther, A.; Bode, J. W. external page"Spontaneous Head-to-Tail Cyclization of Unprotected Linear Peptides with the KAHA Ligation" Chem. Sci. 20156, 4889–4896.

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(109) Mazunin, D.; Broguiere, N.; Zenobi-Wong, M.; Bode, J. W. external page"Synthesis of Biocompatible PEG Hydrogels by pH-Sensitive Potassium Acyltrifluoroborate (KAT) Amide Ligations" ACS Biomater. Sci. Eng. 20151, 456–462.

(108) Geoghegan, K.; Bode, J. W. external page"Bespoke SnAP Reagents for the Synthesis of C-Substituted Spirocyclic and Bicyclic Saturated N-Heterocycles" Org. Lett. 201517, 1934–1937.
- SnAP reagents are commercially available on external pageSIGMA-ALDRICH!

(107) Book chapter: Rohrbacher, F.; Wucherpfennig, T. G.; Bode, J. W. external page"Chemical Protein Synthesis with the KAHA Ligation" Top. Curr. Chem. 2015363, 1–32.

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(105) Harmand, T. J.; Kulkarni, S. S.; Bode, J. W. external page"Optimized Synthesis of a Cyanosulfurylide Linker for Fmoc-SPPS of C-Terminal Peptide α-Ketoacids" Tetrahedron Lett. 201556, 3477–3480.

(104) Saito, F.; Noda, H.; Bode, J. W. external page"Critical evaluation and rate constants of chemoselective ligation reactions for stoichiometric conjugations in water" ACS Chem. Biol. 201510, 1026–1033.
- external pagehighlighted in Nat. Chem. Biol. 201511, 241.

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(103) Schäfer, G.; Leu, L.; Bode, J. W. external page"Synthesis of Unsymmetrical,gem-Disubstituted Bisamides" Heterocycles 201590, 1375–1386. (Special issue)
- Dedicated to Professor Isao Kuwajima on the occasion of his 77th birthday.

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2014

(102) Murar, C. E.; Thuaud, F.; Bode, J. W. external page"KAHA Ligations that form Aspartyl Aldehyde Residues as Synthetic Handles for Protein Modification and Purification" J. Am. Chem. Soc. 2014136, 18140–18148.

(101) Siau, W.-Y.; Bode, J. W. external page"One Step Synthesis of Saturated Spirocyclic N-Heterocycles with SnAP Reagents and Ketones" J. Am. Chem. Soc. 2014136, 17726–17729.
- SnAP reagents are commercially available on external pageSIGMA-ALDRICH!

(100) Review article: Harmand, T. J. R.; Murar, C. E.; Bode, J. W. external page"New chemistries for chemoselective peptide ligations and the total synthesis of proteins" Curr. Opin. Chem. Biol. 201422, 115–121.

(99) Wucherpfennig, T. G.; Pattabiraman, V. R.; Limberg, F. R. P.; Ruiz-Rodríguez, J.; Bode, J. W. external page"Traceless Preparation of C-Terminal α-Ketoacids for Chemical Protein Synthesis by α-Ketoacid–Hydroxylamine Ligation: Synthesis of SUMO2/3" Angew. Chem. Int. Ed. 201453, 12248–12252.

(98) Wucherpfennig, T. G.; Rohrbacher, F.; Pattabiraman, V. R.; Bode, J. W. external page"Formation and Rearrangement of Homoserine Depsipeptides and Depsiproteins in the α-Ketoacid–Hydroxylamine Ligation with 5-Oxaproline" Angew. Chem. Int. Ed. 201453, 12244–12247.
- selected as a Hot Paper.

(97) Huang, Y.-L.; Bode, J. W. external page"Synthetic fermentation of bioactive non-ribosomal peptides without organisms, enzymes or reagents" Nature Chem. 20146, 877–884.
- external pagehighlighted in C&EN.
- external pagehighlighted in Chemistry World.
- external pageInterviewNature Chem. 20146, 846–847.
- external pagehighlighted in Nat. Chem. Biol. 201410, 984.

(95) Erős, G.; Kushida, Y.; Bode, J. W. external page"A Reagent for the One-Step Preparation of Potassium Acyltrifluoroborates (KATs) from Aryl- and Heteroarylhalides" Angew. Chem. Int. Ed. 201453, 7604–7607.
- selected as a Hot Paper.
- external pagereviewed in Synfacts 201410, 1071. 

(94) Hsieh, S.-Y.; Bode, J. W. external page"(4aR,9aS)-4-Hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one" e-EROS 2014, Published Online. (DOI: 10.1002/047084289X.rn01654)

(92) Hsieh, S.-Y.; Wanner, B.; Wheeler, P.; Beauchemin, A. M.; Rovis, T; Bode, J. W. external page"Stereoelectronic Basis for the Kinetic Resolution of N-Heterocycles with Chiral Acylating Reagents" Chem. Eur. J. 201420, 7228–7231.

(91) Schäfer, G.; Bode, J. W. external page"The Synthesis of Sterically Hindered Amides" CHIMIA 201468, 252–255.
- On the occasion of the SCS-Metrohm Foundation Award for best oral presentation at the Fall Meeting 2013.

(89) Review article: Vo, C.-V.; Bode, J. W. external page"Synthesis of Saturated N-Heterocycles" J. Org. Chem. 201479, 2809–2815.
- SnAP reagents are commercially available on external pageSIGMA-ALDRICH!

(88) Schäfer, G.; Bode, J. W. external page"Synthesis of Sterically HinderedN-Acylated Amino Acids fromN-Carboxyanhydrides" Org. Lett. 201416, 1526–1529.
- external pagereviewed in Synfacts 201410, 635.
- external pagehighlighted in Org. Process Res. Dev. 201418, 562–572. 

(87) Vo, C.-V.; Luescher, M. U.; Bode, J. W. external page"SnAP Reagents for the One-Step Synthesis of Medium Ring Saturated N-Heterocycles from Aldehydes" Nature Chem. 20146, 310–314.
- external pagehighlighted in C&EN.
- external pagehighlighted in CHIMIA.
- external pagehighlighted in Synfacts 201410, A108.
- SnAP reagents are commercially available on external pageSIGMA-ALDRICH!

(86) Luescher, M. U.; Vo, C.-V.; Bode, J. W. external page"SnAP Reagents for the Synthesis of Piperazines and Morpholines" Org. Lett. 201416, 1236–1239.
- external pagehighlighted in C&EN.
- external pageabstracted in ChemInform 2014, published online. (DOI: 10.1002/chin.201432028)
- SnAP reagents are commercially available on external pageSIGMA-ALDRICH!

(85) Review article: Mahatthananchai, J.; Bode, J. W. external page"On the Mechanism of N-Heterocyclic Carbene-Catalyzed Reactions Involving Acyl Azoliums" Acc. Chem. Res. 201447, 696–707.

2013

(84) Book chapter: Mahatthananchai, J.; Bode, J. W. external page"Catalytic Reactions with N-Mesityl Substituted N-Heterocyclic Carbenes" Contemporary Carbene Chemistry 2013, 237–273. [Eds: Robert A. Moss / Michael P. Doyle]

(83) News and views: Bode, J. W. external page"Carbene catalysis: An internal affair" Nature Chem. 2013, 5, 813–815.

(82) Teichert, J. F.; Mazunin, D.; Bode, J. W. external page"Chemical Sensing of Polyols with Shapeshifting Boronic Acids as a Self-Contained Sensor Array" J. Am. Chem. Soc. 2013, 135, 11314–11321.
- external pagehighlighted in Spotlights on Recent JACS Publications, J. Am. Chem. Soc. 2013, 135, 11679–11679.

(81) Gondo, C. A.; Bode, J. W. external page"Catalytic Redox Amidations of Aldehydes with a Polymer-Supported Peptide-N-Heterocyclic Carbene Multifunctional Catalyst" Synlett 2013, 24, 1205–1210.
- Cluster Issue on Carbene Catalysis

2012

(78) Chiang, Y.-L; Russak, J. A.; Carrillo, N; Bode, J. W. external page"Synthesis of Enantiopure Isoxazolidine Monomers for the Preparation of β3-Oligopeptides by Iterative α-Ketoacid–Hydroxylamine (KAHA) Ligations" Helv. Chim. Acta 2012, 2481–2501.
- Dedicated to Professor Dieter Seebach on the occasion of his 75th birthday

(77) He, M.; Rommel, M.; Bode, J. W. external page"Formal Synthesis of (±)-Clausenamide by NHC-Catalyzed γ-Lactam Formation" Heterocycles 2012, 86, 1689–1696. (Special issue)

(76) Book chapter: Mahatthananchai, J.; Bode, J. W. external page"Enantioselective Annulations With Chiral N-Mesityl N-Heterocyclic Carbenes" Asymmetric Synthesis: The Essentials II, 2012, 67–77. [Eds: Christmann, Mathias / Bräse, Stefan]

(75) Review article: Mahatthananchai, J.; Dumas, A. M.; Bode, J. W. external page"Catalytic Selective Synthesis" Angew. Chem. Int. Ed. 2012, 51, 10954–10990.
- Dedicated to Professor Michael P. Doyle on the occasion of his 70th birthday
- external pagehighlighted in Org. Process Res. Dev. 2013, 17, 160–168.

5616951

(74) Kreituss, I.; Murakami, Y.; Binanzer, M.; Bode, J. W. external page"Kinetic Resolution of Nitrogen Heterocycles with a Reusable Polymer-Supported Reagent" Angew. Chem. Int. Ed. 2012, 51, 10660–10663.
- external pagehighlighted in Org. Process Res. Dev. 2012, 16, 1674–1683.

(73) Book Chapter: Bode, J. W. external page"Reinventing Amide Bond Formation" Top. Organomet. Chem. 2013, 44, 13–33.

(72) Ogunkoya, A. O.; Pattabiraman, V. R.; Bode, J. W. external page"Sequential α-Ketoacid-Hydroxylamine (KAHA) Ligations: Synthesis of C-Terminal Variants of the Modifier Protein UFM1" Angew. Chem. Int. Ed. 2012, 51, 9693–9697.
- external pageCorrigendum: Angew. Chem. Int. Ed. 2014, 53, 12005.

(70) Schäfer, G.; Matthey, C.; Bode, J. W. external page"Facile Synthesis of Sterically Hindered and Electron-Deficient Secondary Amides from Isocyanates" Angew. Chem. Int. Ed. 2012, 51, 9173–9175.
- selected as a Hot Paper.

(69) Hsieh, S.-Y.; Binanzer, M.; Kreituss, I.; Bode, J. W. external page"Expanded substrate scope and catalyst optimization for the catalytic kinetic resolution of N-heterocycles" Chem. Commun. 2012, 48, 8892–8894.
- external pageabstracted in ChemInform 2012, published online. (DOI: 10.1002/chin.201249022)

(68) Book chapter: Gondo, C. A.; Bode, J. W. "1,2,4-Triazolium Salts", Science of Synthesis: Houben Weyl Methods of Molecular Transformations, Vol. 13.33, 2012, Georg Thieme Verlag, 199–214. [Ed: B. List]

(67) Allen, S. E.; Mahatthananchai, J.; Bode, J. W.; Kozlowski, M. C. external page"Oxyanion-steering and CH-π Interactions as Key Elements in a N-Heterocyclic Carbene-Catalyzed [4+2] Cycloaddition" J. Am. Chem. Soc. 2012, 134, 12098–12103
- external pagehighlighted in CHIMIA 2012, 66, 801.

(66) Dumas, A. M., Molander, G. A., Bode, J. W. external page"Amide-Forming Ligation of Acyltrifluoroborates and Hydroxylamines in Water" Angew. Chem. Int. Ed. 2012, 51, 5683–5686.

(65) Dumas, A. M.; Bode, J. W. external page"Synthesis of Acyltrifluoroborates" Org. Lett. 2012, 14, 2138–2141.
- external pagehighlighted in Org. Process Res. Dev. 2012, 16, 1244–1257.

(63) Larson, K. K.; He, M.; Teichert, J. F.; Naganawa, A.; Bode, J. W. external page"Chemical Sensing with Shapeshifting Organic Molecules" Chem. Sci. 2012, 3, 1825–1828.
- external pagehighlighted in Nature Chem. 2012, 4, 336–337.

(62) Pattabiraman, V. R.; Ogunkoya, A. O.; Bode, J. W. external page"Chemical Protein Synthesis by Chemoselective α-Ketoacid–Hydroxylamine (KAHA) Ligations with 5-Oxaproline" Angew. Chem. Int. Ed. 2012, 51, 5114–5118.
- external pageselected as a Hot Paper & Cover.
- external pageCorrigendum: Angew. Chem. Int. Ed. 2014, 53, 12005.

(61) Gerfaud, T.; Chiang, Y.-L.; Kreituss, I.; Russak, J.; Bode, J. W.; external page"Enantioselective, chromatography-free synthesis ofβ3-amino acids with natural and unnatural side chains" Org. Process Res. Dev. 2012, 16, 687–696.

(60) Fukuzumi, T.; Ju, L.; Bode, J. W. external page"Chemoselective Cyclization of Unprotected Linear Peptides by alpha-Ketoacid–Hydroxyamine Amide-Ligation" Org. Biomol. Chem. 2012, 10, 5837–5844.
- This article is part of the collection: Organic & Biomolecular Chemistry 10th Anniversary.

(59) Book chapter: Chiang, P.-C.; Bode, J. W. "N-Heterocyclic Carbene Catalyzed Reactions of alpha-Functionalized Aldehydes", Science of Synthesis: Asymmetric Organocatalysis, Vol. 1, 2012, Georg Thieme Verlag, 639–672. [Ed: B. List]

(57) Pusterla, I.; Bode, J. W. external page"The Mechanism of the α-Ketoacid–Hydroxylamine (KAHA) Amide-Forming Ligation" Angew. Chem. Int. Ed. 2012, 51, 513–516.

(56) Mahatthananchai, J.; Bode, J. W. external page"The effect of the N-mesityl group in NHC-catalyzed reactions" Chem. Sci. 2012, 3, 192–197.

(55) Huang, Y.-L.; Frey, R; Juarez-Garcia, M. E.; Bode, J. W. external page"Synthesis of Aza-Surfactin and 3-Epi-aza-surfactin" Heterocycles 2012, 84, 1179–1191

2011

(54) Review article: Pattabiraman, V.; Bode, J. W. external page"Rethinking Amide Bond Synthesis” Nature 2011, 480, 471–479.

a

(53) Binanzer, M.; Hsieh S.-Y.; Bode, J. W. external page"Catalytic Kinetic Resolution of Cyclic Secondary Amines" J. Am. Chem. Soc. 2011, 133, 19698–19701.
- external pagereviewed in Synfacts 2012, 8, 211.

(52) Wanner, B.; Mahatthananchai, J.; Bode, J. W. external page"Enantioselective Synthesis of Dihydropyridinones via NHC-Catalyzed Aza-Claisen Reaction" Org. Lett. 2011, 13, 5378–5381.

(51) Schäfer, G.; Bode, J. W. external page"Friedel-Crafts Benzylation of Activated and Deactivated Arenes" Angew. Chem. Int. Ed. 2011, 50, 10913–10916.
- external pagereviewed in Synfacts 2012, 8, 194.
- external pagehighlighted in Org. Process Res. Dev. 2012, 16, 526–534.
- external pagehighlighted in Organic Chemistry Portal.

(49) Wu, J.; J. Ruiz-Rodríguez; Comstock, J. M.; Dong, J. Z.; Bode, J. W. external page"Synthesis of human GLP-1 (7–36) by chemoselective α-ketoacid–hydroxylamine peptide ligation of unprotected fragments" Chem. Sci. 2011, 2, 1976–1979.

4

(45) Chiang, P.-C.; Bode, J. W. external page"On the Role of CO2 in NHC-Catalyzed Oxidation of Aldehydes" Org. Lett. 2011, 13, 2422–2425.

(42) Book chapter: Hackenberger, C. P. R.; Bode, J. W.; Schwarzer, D. external page"Chemoselective Peptide Ligation: A Privileged Tool for Protein Synthesis" Amino Acids, Peptides and Proteins in Organic Chemistry: Building Blocks, Catalysis and Coupling Chemistry, Volume 3 (ed A. B. Hughes), 2011.

(41) Review article: Chiang, P.-C.; Bode, J. W. external page"N-Heterocyclic Carbenes as Organic Catalysts" in N-Heterocyclic Carbenes: From Laboratory Curiosities to Efficient Synthetic Tools; Díez-González, S., Ed.; RSC Catalysis Series No. 6; Royal Society of Chemistry: Cambridge, 2011; pp 399–435. (DOI: 10.1039/9781849732161-00399)

2010

(40) Lippert, A. R.; Naganawa, A.; Keleshian, V. L.; Bode, J. W. external page"Synthesis of Phototrappable Shape-Shifting Molecules for Adaptive Guest Binding" J. Am. Chem. Soc. 2010, 132, 15790–15799.

(37) Yu, S.; Ishida, H.; Juarez-Garcia, M. E.; Bode, J. W. external page"Unified synthesis of enantiopure β2h, β3h and β2,3-amino acids" Chem. Sci. 2010, 637–641.

(36) Kaeobamrung, J.; Mahatthananchai, J.; Zheng, P.; Bode, J. W. external page"An Enantioselective Claisen Rearrangement Catalyzed by N-Heterocyclic Carbenes" J. Am. Chem. Soc. 2010, 132, 8810–8812.
- external pagereviewed in Synfacts 2010, issue 09, 1071.

(31) Flores, M. A.; Bode, J. W. external page"Chemoselective Protection of α-Ketoacids by Direct Annulations with Oximes" Org. Lett. 2010, 12, 1924–1927.

(30) Mitchell, T. A.; Bode, J. W. external page"Synthesis of Dialkyl Ethers from Organotrifluoroborates and Acetal" J. Am. Chem. Soc. 2009, 131,18057–18059.
- external pagereviewed in Synfacts 2010, issue 03, 335.

2009

(29) Chiang, P.-C.; Kim, Y.; Bode, J. W. external page"Catalytic Amide Formation with α'-Hydroxyenones as Acylating Reagents" Chem. Commun., 2009, 4566–4568.
- external pagereviewed in Synfacts 2009, issue 09, 1042.

7
7

(27) Valenta, P.; Drucker, N. A.; Bode, J. W. and Walsh, P. J. external page"Simple One-pot Conversion of Aldehydes and Ketones to Enals" Org. Lett. 2009, 11, 2117–2119.

8
8

(22) Lippert, A. R.; Keleshian, V. L.; Bode, J. W. external page"Dynamic supramolecular complexation by shapeshifting organic molecules" Org. Biomol. Chem. 2009, 7, 1529–1532.

5

2008

(20) Rommel, M.; Fukuzumi, T.; Bode, J. W. external page"Cyclic Ketimines as Superior Electrophiles for NHC-Catalyzed Homoenolate Additions with Broad Scope and Low Catalyst Loadings" J. Am. Chem. Soc. 2008, 130, 17266–17267.
- external pagereviewed in Synfacts 2009, issue 02, 216.

(18) Struble, J. R.; Bode, J. W. external page"A modular synthesis of chiral aminoindanol-derived imidazolium salts" Tetrahedron 2008, 64, 6961–6972.

(16) Struble, J.R.; Kaeobamrung, J.; Bode, J.W. external page"Synthesis of an N-Mesityl Substituted Chiral Imidazolium Salt for NHC-Catalyzed Reactions" Org. Lett. 2008, 10, 957–960.
- external pagereviewed in Synfacts 2008, issue 06, 645.

2007

(13) Chiang, P.-C.; Kaeobamrung, J.; Bode, J. W. external page"Enantioselective, Cyclopentene-Forming Annulations via NHC-Catalyzed Benzoin–Oxy-Cope Reactions" J. Am. Chem. Soc. 2007, 129, 3520–3521.
- external pagereviewed in Synfacts 2007, issue 05, 545.

2006

(12) He, M.; Uc, G. J.; Bode, J. W. external page"Chiral, N-Heterocyclic Carbene Catalyzed Oxodiene Diels-Alder Reactions with Low Catalyst Loadings" J. Am. Chem. Soc. 2006, 128, 15088–15089.
- external pagereviewed in Synfacts 2007, issue 01, 100.

(11) Review article: Bode, J. W. external page"Emerging Methods for the Synthesis of Amide and Peptide Bonds" Curr. Opin. Drug Discov. Devel. 2006, 9, 765–775.

(10) Lippert, A. R.; Kaeobamrung, J.; Bode, J. W. external page"Synthesis of Oligosubstituted Bullvalones: Shapeshifiting Molecules Under Basic Conditions ", J. Am. Chem. Soc. 2006, 128, 14738–14739.

(9) Sohn, S. S.; Bode, J. W. external page"N-Heterocyclic Carbene Catalyzed C–C Bond Cleavage in Redox Esterifications of Chiral Formylcyclopropanes" Angew. Chem. Int. Ed. 2006, 6021–6024.
- external pagereviewed in Synfacts 2006, issue 10, 1060.

(8) He, M.; Struble, J. R.; Bode, J. W. external page"Highly Enantioselective Azadiene Diels-Alder Reactions Catalyzed by Chiral N-Heterocyclic Carbenes" J. Am. Chem. Soc. 2006, 128, 8418–8420.
- external pagereviewed in Synfacts 2006, issue 08, 840.

1

(7) Carrillo, N.; Davalos, E. A.; Russak, J. A.; Bode, J. W. external page"Iterative, Aqueous Synthesis of b3-oligopeptides without Coupling Reagents" J. Am. Chem. Soc. 2006, 128, 1452-1453.external page
- external pagehighlighted in C&E News.

2005

(4) He, M.; Bode, J. W. external page"Catalytic Synthesis of gamma-Lactams via Direct Annulations of Enals and N-Sulfonylimines" Org. Lett. 2005, 7, 3131–3134.
- external pagehighlighted in Angew. Chem. Int. Ed. 2005, 44, 7506.

2004

(3) Bode, J. W. external page"Reactor, Chem Axon" J. Am. Chem. Soc. 2004, 126, 15317. (Software Review)

(2) Sohn, S. S.; Rosen, E. L.; Bode, J. W. external page"N-Heterocyclic Carbene-Catalyzed Generation of Homoenolates: gamma-Butyrolactones by Direct Annulations of Enals and Aldehydes" J. Am. Chem. Soc. 2004, 126, 14370-14371.
- external pagehighlighted in Angew. Chem. Int. Ed. 2005, 44, 7506.

(1) Chow, K. Y.-K.; Bode, J. W. external page"Catalytic Generation of Activated Carboxylates: Direct, Stereoselective Synthesis of beta-Hydroxyesters from Epoxyaldehydes" J. Am. Chem. Soc. 2004, 126, 8126–8127.
- external pagehighlighted in Angew. Chem. Int. Ed. 2005, 44, 7506.

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