SNF-Funded Publications

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Publications by year:
 2017 2016 2015 2014 2012 2011

2017

(138) Murar, C. E.; Harmand, T. J.; Bode, J. W.; "Improved synthesis of (S)-N-Boc-5-oxaproline for protein synthesis with the α-ketoacid-hydroxylamine (KAHA) ligation" Bioorg. Med. Chem. 2017, Article in Press

138
137
136

2016

(125) Thuaud, F.; Rohrbacher, F.; Zwicky, A.; Bode, J. W.; "Photoprotected Peptide α-Ketoacids and Hydroxylamines for Iterative and One-Pot KAHA Ligations: Synthesis of NEDD8" Helv. Chim. Acta 2016, 99, 868–894

125

(123) Wucherpfennig, T. G.; Müller, S; Wolfrum, C.; Bode, J. W.; "Chemical Synthesis of the 12 kDa Human Myokine Irisin by α-Ketoacid-Hydroxylamine (KAHA) Ligation" Helv. Chim. Acta 201699, 897–907

123

(122) Thuaud, F.; Rohrbacher, F.; Zwicky, A.; Bode, J. W.; "Incorporation of Acid-Labile Masking Groups for the Traceless Synthesis of C-Terminal Peptide α-Ketoacids" Org. Lett. 201618, 3670–3673

122

(121) Harmand, T. J.; Murar, C. E.; Bode, J. W.; "Protein chemical synthesis by α-ketoacid-hydroxylamine ligation" Nature Protocols 2016, 11, 1130-1147

121

2015

(115) He, C.; Kulkarni, S. S.; Thuaud, F.; Bode, J. W. "Chemical Synthesis of the 20 kDa Heme Protein Nitrophorin 4 by α-Ketoacid-Hydroxylamine (KAHA) Ligation" Angew. Chem. Int. Ed. 2015, 54, 12996–13001.

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(111)  Pusterla, I.; Bode, J. W. "An oxazetidine amino acid for chemical protein synthesis by rapid, serine-forming ligations" Nature Chem. 20157, 668–672.

111

(110) Rohrbacher, F.; Deniau, G.; Luther, A.; Bode, J. W. "Spontaneous Head-to-Tail Cyclization of Unprotected Linear Peptides with the KAHA Ligation" Chem. Sci. 20156, 4889–4896.

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(107) Book chapter: Rohrbacher, F.; Wucherpfennig, T. G.; Bode, J. W. "Chemical Protein Synthesis with the KAHA Ligation" Top. Curr. Chem. 2015363, 1–32.

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(105) Harmand, T. J.; Kulkarni, S. S.; Bode, J. W. "Optimized Synthesis of a Cyanosulfurylide Linker for Fmoc-SPPS of C-Terminal Peptide α-Ketoacids" Tetrahedron Lett. 201556, 3477–3480.

a

(104) Saito, F.; Noda, H.; Bode, J. W. "Critical evaluation and rate constants of chemoselective ligation reactions for stoichiometric conjugations in water" ACS Chem. Biol. 201510, 1026–1033.
- highlighted in Nat. Chem. Biol. 201511, 241.

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2014

(102) Murar, C. E.; Thuaud, F.; Bode, J. W. "KAHA Ligations that form Aspartyl Aldehyde Residues as Synthetic Handles for Protein Modification and Purification" J. Am. Chem. Soc. 2014136, 18140–18148.

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(100) Review article: Harmand, T. J. R.; Murar, C. E.; Bode, J. W. "New chemistries for chemoselective peptide ligations and the total synthesis of proteins" Curr. Opin. Chem. Biol. 201422, 115–121.

(99) Wucherpfennig, T. G.; Pattabiraman, V. R.; Limberg, F. R. P.; Ruiz-Rodríguez, J.; Bode, J. W. "Traceless Preparation of C-Terminal α-Ketoacids for Chemical Protein Synthesis by α-Ketoacid–Hydroxylamine Ligation: Synthesis of SUMO2/3" Angew. Chem. Int. Ed. 201453, 12248–12252.

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(98) Wucherpfennig, T. G.; Rohrbacher, F.; Pattabiraman, V. R.; Bode, J. W. "Formation and Rearrangement of Homoserine Depsipeptides and Depsiproteins in the α-Ketoacid–Hydroxylamine Ligation with 5-Oxaproline" Angew. Chem. Int. Ed. 201453, 12244–12247.
- selected as a Hot Paper.

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(97) Huang, Y.-L.; Bode, J. W. "Synthetic fermentation of bioactive non-ribosomal peptides without organisms, enzymes or reagents" Nature Chem. 20146, 877–884.
- highlighted in C&EN.
- highlighted in Chemistry World.
- InterviewNature Chem. 20146, 846–847.
- highlighted in Nat. Chem. Biol. 201410, 984.

2012

(78) Chiang, Y.-L; Russak, J. A.; Carrillo, N; Bode, J. W. "Synthesis of Enantiopure Isoxazolidine Monomers for the Preparation of β3-Oligopeptides by Iterative α-Ketoacid–Hydroxylamine (KAHA) Ligations" Helv. Chim. Acta 2012, 2481–2501.
- Dedicated to Professor Dieter Seebach on the occasion of his 75th birthday

(73) Book Chapter: Bode, J. W. "Reinventing Amide Bond Formation" Top. Organomet. Chem. 2013, 44, 13–33.

(72) Ogunkoya, A. O.; Pattabiraman, V. R.; Bode, J. W. "Sequential α-Ketoacid-Hydroxylamine (KAHA) Ligations: Synthesis of C-Terminal Variants of the Modifier Protein UFM1" Angew. Chem. Int. Ed. 2012, 51, 9693–9697.
- Corrigendum: Angew. Chem. Int. Ed. 2014, 53, 12005.

21

(62) Pattabiraman, V. R.; Ogunkoya, A. O.; Bode, J. W. "Chemical Protein Synthesis by Chemoselective α-Ketoacid–Hydroxylamine (KAHA) Ligations with 5-Oxaproline" Angew. Chem. Int. Ed. 2012, 51, 5114–5118.
- selected as a Hot Paper & Cover.
- Corrigendum: Angew. Chem. Int. Ed. 2014, 53, 12005.

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(61) Gerfaud, T.; Chiang, Y.-L.; Kreituss, I.; Russak, J.; Bode, J. W.; "Enantioselective, chromatography-free synthesis ofβ3-amino acids with natural and unnatural side chains" Org. Process Res. Dev. 2012, 16, 687–696.

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(60) Fukuzumi, T.; Ju, L.; Bode, J. W. "Chemoselective Cyclization of Unprotected Linear Peptides by alpha-Ketoacid–Hydroxyamine Amide-Ligation" Org. Biomol. Chem. 2012, 10, 5837–5844.
- This article is part of the collection: Organic & Biomolecular Chemistry 10th Anniversary.

(57) Pusterla, I.; Bode, J. W. "The Mechanism of the α-Ketoacid–Hydroxylamine (KAHA) Amide-Forming Ligation" Angew. Chem. Int. Ed. 2012, 51, 513–516.

a

(55) Huang, Y.-L.; Frey, R; Juarez-Garcia, M. E.; Bode, J. W. "Synthesis of Aza-Surfactin and 3-Epi-aza-surfactin" Heterocycles 2012, 84, 1179–1191

2011

(54) Review article: Pattabiraman, V.; Bode, J. W. "Rethinking Amide Bond Synthesis” Nature 2011, 480, 471–479.

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(49) Wu, J.; J. Ruiz-Rodríguez; Comstock, J. M.; Dong, J. Z.; Bode, J. W. "Synthesis of human GLP-1 (7–36) by chemoselective α-ketoacid–hydroxylamine peptide ligation of unprotected fragments" Chem. Sci. 2011, 2, 1976–1979.

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