Open Source Notes

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Past OC VI Lecture Notes


Topics Note Files Update Year
Asymmetric Hydrogenation PDF (PDF, 1.6 MB) | Word (DOC, 5.6 MB) 2015
Catalyst Design, Synthesis and Screening PDF (PDF, 4.6 MB) | Word (DOCX, 9.1 MB) 2012
Catalytic C-H Functionalization PDF (PDF, 1.4 MB) | Word (DOCX, 2.9 MB) 2012
Catalytic Divergent Synthesis PDF (PDF, 2.1 MB) | Word (DOC, 4.6 MB) 2011
Catalytic Enantioselective 1,2 Additions PDF (PDF, 2.1 MB) | Word (DOCX, 4.9 MB) 2012
Catalytic Enantioselective 1,4 Additions PDF (PDF, 1.8 MB) | Word (DOC, 8.2 MB) 2015
Catalytic Enantioselective Synthesis of Amino Acids PDF (PDF, 1.3 MB) | Word (DOC, 2.8 MB) 2015
Cooperative Catalysis PDF (PDF, 2.1 MB) | Word (DOCX, 3.3 MB) 2015
Enantioselective Aldol Reactions PDF (PDF, 1.6 MB) | Word (DOCX, 3.7 MB) 2011
Enantioselective Olefin Addition Reactions PDF (PDF, 2.4 MB) | Word (DOC, 3.6 MB) 2015
Fluorination PDF (PDF, 1.5 MB) | Word (DOCX, 3.5 MB) 2012
Key Concepts in Catalysis, Thermodynamics and Kinetics PDF (PDF, 3.6 MB) | Word (DOC, 11.8 MB) 2015
Key Concepts in Stereoselective Synthesis PDF (PDF, 1.7 MB) | Word (DOC, 3 MB) 2015
Kinetic Resolution and Desymmetrization PDF (PDF, 4.4 MB) | Word (DOCX, 4.5 MB) 2015
Ligation and Bioconjugation PDF (PDF, 1.7 MB) | Word (DOCX, 5.5 MB) 2015
Machine-Assisted Organic Synthesis PDF (PDF, 1.9 MB) | Word (DOCX, 3.4 MB) 2015
N-Heterocyclic Carbene Catalysis PDF (PDF, 3.7 MB) | Word (DOC, 7.5 MB) 2013
Photoredox Catalysis PDF (PDF, 1.6 MB) | Word (DOCX, 2.9 MB) 2015
Saturated N-Heterocycle Synthesis PDF (PDF, 1.7 MB) | Word (DOCX, 3.3 MB) 2015
Selective Catalysis PDF (PDF, 2.6 MB) | Word (DOCX, 4.7 MB) 2015

About these notes


These chapters were written and illustrated by the PhD students and postdocs in Professor Bode’s research group at ETH-Zürich as the “script” for OC VI: Advanced Methods and Strategies in Organic Chemistry. Professor Bode’s group members (and a few from the Hilvert group) put an enormous amount of time and effort into preparing these chapters! They are designed to present the background and development of both historical and contemporary topics in organic chemistry. All entries are based on the primary literature and citations provided. In nearly all cases, the schemes have been redrawn in Chemdraw and are available for use or modification without copyright violations. The notes are updated from time to time and 2-3 new chapters per year are created. In a future project, we will prepare these notes in eBook format for better reading on tablet devices.

How can I use these notes?

These notes can be used as a reference or study guide. We are making available the original word files with editable Chemdraw. Please use Chemdraw 12.0.3 and Word 2011 14.4.3 (for Macintosh) to ensure that the Chemdraw structures are available for “round-trip editing”. You may use all or part of the notes for your own projects, classes, or chapters provided the following conditions are met.

What are requirements for the use of these materials?

The purpose of this website is to make course materials used in courses taught by Professor Bode’s group at ETH-Zürich freely and openly available to others for non-commercial educational purposes. Through this website, Professor Bode grants the right to anyone to use the materials, either “as is”, or in a modified form. There is no restriction on how a user can modify the materials for their purpose but the user must meet the three requirements below in order to use the materials:

1. Non-commercial: Use of these materials is open to all except for profit-making entities who charge a fee for access to educational materials.

2. Attribution: Any and all use or reuse of the material, including use of derivative works (new materials that incorporate or draw on the original materials), must be attributed to Professor Bode and, if another group member's name is associated with the material, to that person as well.

3. Share alike (aka "copyleft"): Any publication or distribution of original or derivative works, including production of electronic or printed class materials or placement of materials on a Web site, must offer the works freely and openly to others under the same terms that these materials were first made available to the user.

If you would like to use Professor Bode’s course materials, but you are unsure whether your intended use qualifies as non-commercial use, please contact Professor Bode ().

Non-commercial use

Non-commercial use means that users may not sell, profit from, or commercialize any of these materials or works derived from them. The guidelines below are intended to help users determine whether or not their use of these materials would be permitted under the "non-commercial" restriction of the Creative Commons License. Note that there are additional requirements (attribution and share alike) spelled out in our license.

1. Commercialization is prohibited. Users may not directly sell or profit from these materials or from works derived from them.

2. Determination of commercial vs. non-commercial purpose is based on the use, not the user. Materials may be used by individuals, institutions, governments, corporations, or other business whether for-profit or non-profit so long as the use itself is not a commercialization of the materials or a use that is directly intended to generate sales or profit.

3. Incidental charges to recover reasonable reproduction costs may be permitted. Recovery of nominal actual costs for copying small amounts (under 1000 copies) of these materials on paper or CDs is allowed for educational purposes so long as there is no profit motive and so long as the intended use of the copies is in compliance with all license terms. However, students must be informed that the materials are freely available on this website.

Intellectual property

The intellectual property policies created for these materials are clear and consistent with other policies for scholarly materials used in education. The Bode Group has reviewed all material extensively to determine the correct ownership of the material and obtain the appropriate licenses to make the material openly available on the Web. We will promptly remove any material that is determined to be infringing on the rights of others. If you believe that any of these materials infringes another's copyright, please inform Professor Bode ().

Cite reuse of these materials

If you choose to reuse or repost these materials you must give proper attribution to the original author(s). Please utilize the following citation:
[Name], [Course Title][Topic][Semester]. (ETH-Zürich), [URL] (Accessed [Date]). License: Creative commons BY-NC-SA


Jeffrey W. Bode, OC IV: Advanced Methods and Strategies in SynthesisKey Concepts in Stereoselective Synthesis2013. (ETH-Zürich), License: Creative commons BY-NC-SA

If you want to use the materials on your Web site, you must also include a copy of Professor Bode’s Creative Commons License, or a clear and reasonable link to its URL with every copy of the materials or the derivative work you create from it.

What if I find mistakes?

There are mistakes in these chapters. If you find one, please let us know or –better yet – fix the mistake and send us the revised Word file. We cannot cite every paper on every topic and there are certainly omissions. If we are missing key references or precedents please incorporate them into the documents and send us the new files. We’ll do our best to correct everything in the new editions, which we usually update once a year.

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